Matthew Stafford (Det vs. Phi) – Stafford played maybe the best game of his career against the Eagles last season. He completed 27 of 38 attempts (71%) for 337 yards and 5 TDs with 0 turnovers (38.2 FP).
Cam Newton (Car vs. TB) – It’s been a fantasy bonanza for Cam in his last two home games against the Bucs. Last year he toasted them 293 passing yards, 2 passing TDs and another 2 TDs on the ground (35.7 FP) and in 2014 he rolled up 263 passing yards, 2 passing TDs and 68/1 on the ground (34.0 FP).
Brian Hoyer (Chi vs. Ind) – Hoyer had one of his better games 2015 as a Houston Texan against the Colts. He completed 77.4% of his passes for 312 yards, 2 TDs, 1 INT and added a 14-yard run for a total of 25.0 FP.
Arian Foster (Mia vs. Ten) – Foster is a question mark for this week but in the event that he does go, we’ll note that his history against the Titans is very strong. He did not face them in 2015 but he averaged a whopping 30.4 FP against the in two 2014 meetings. Going back even further, he has never scored fewer than 12.0 FP against them in 8 career games.
Lamar Miller (Hou @ Min) – Miller had a big day in his only career game so far against the Vikings back in 2014. He carried 19 times for 92 yards and TD and added another 58 yards on 5 catches (26.0 FP)
Latavius Murray (Oak vs. SD) – Murray rushed for a TD in each of his two games against San Diego last year and put up 19.2 FPG. He averaged 17 carries for 82 yards and a TD on the ground and 3 catches for 20 yards through the air in those meetings.
DeMarco Murray (Ten @ Mia) – It was an uneven season for Murray last year in Philly but he did get a large workload in their Week 10 game against the Dolphins. He earned 28 touches and gained 119 yards and totaled 17.9 FP even though he did not score.
Theo Riddick (Det vs. Phi) – Riddick had a productive day as a receiver in Week 12, 2015 against the Eagles. He only carried twice for 6 yards but caught all 5 of his targets 5 for 62 yards and a TD (17.8 FP).
Kelvin Benjamin (Car vs. TB) – Benjamin averaged 19.8 FP in his two games against the Bucs in 2014. He was targeted a total of 20 times in those games catching 14 for 196 yards and a score.
Larry Fitzgerald (Ari @ SF) – Larry Fitz was a 49er killer in 2015 posting stat lines of 9/134/2 and 10/66/0 (25.5 FPG). He has gained more yards against the 49ers in his career than against any other team.
Golden Tate (Det vs. Phi) – This year has been brutal so far for Tate but he had a very Tate-like stat line against the Eagles last year catching 7 of 8 targets for 50 yards and a TD (18.0 FP).
Vincent Jackson (TB @ Car) – VJax only faced the Panthers once in 2015 but beat them for 10 catches, 147 yards and a TD on 15 targets (30.7 FP). It was his biggest fantasy performance since Week 7, 2013.
Michael Crabtree (Oak vs. SD) – Crabtree caught 6 balls with a TD in each of his two games against the Chargers last year (17.1 FPG).
Ted Ginn (Car vs. TB) – Ginn only caught 2 balls in his most recent meeting with the Buccaneers but both of them went for touchdowns earning him 15.8 FP. Ginn has scored on 3 of his last 4 catches in this series and has scored at least 12.0 FP in three straight.
Devin Funchess (Car vs. TB) – Funchess has his best fantasy day as a prom against the Bucs in Week 16 last year. He was targeted a career-high 8 times and caught 7 of them for 120 yards and a TD (25.0 FP).
Vance McDonald (SF vs. Ari) – McDonald had his best game as a pro in Week 12 of last year against the Cardinals. He caught a career-high 6 of 7 targets for 71 yards and a TD (19.1 FP).
Delanie Walker (Ten @ Mia) – Walker was targeted 10 times against the Dolphins in Week 6, 2015. He caught 8 of them for 97 yards and 17.7 FP.
Marcus Mariota (Ten @ Mia) – Mariota managed just 219 yards through the air and 0.0 yards on the ground against Miami last year. He did throw a TD in that game but also had two picks and totaled only 15.0 FP.
Melvin Gordon (SD @ Oak) – Gordon wasn’t much of a factor against the Raiders in Week 7 of last season. He carried only 7 times for 29 yards and did not have any pass targets (2.9 FP).
LeGarrette Blount (NE @ Cle) – Blount has faced the Browns three times in his career (two as a Steeler and one as a Patriot) and he wasn’t a big part of the game plan in any of those games. He’s never carried more than 8 times or scored double-digit fantasy points against them.
Darren Sproles (Phi @ Det) – 25 total yards is all Sproles could muster against Detroit last year. He was targeted 6 times and caught 4 of them but earned just 6.5 FP.
Carlos Hyde (SF vs. Ari) – Hyde scored just 7.1 FP against the Cardinals in their Week 3 meeting last year. He carried 15 times but only gained 51 yards (3.4 YPC) and caught only 1 pass for 10 yards.
Michael Floyd (Ari @ SF) – Floyd did nothing in two games against the Niners last year. He caught just 1 pass in each game and did not score (2.3 FPG).
Torrey Smith (SF vs. Ari) – Smith posted 0.0 FP against the Cardinals in Week 3 of last season and followed that up with a 2/51/0 performance in Week 12 (3.6 FPG).
Mike Evans (TB @ Car) – This matchup has not been a kind one to Evans. He’s averaging 9.5 FPG against them in four meetings but hasn’t topped 40 yards in three of them and has only scored in one of them and has caught just 42% of his targets.
Greg Olsen (Car vs. TB) – Olsen was unusually quiet in his two games against Tampa Bay last year posting 2/28 in the first and 2/16 in the second (4.2 FPG).
Eric Ebron (Det vs. Phi) – Ebron was a non-factor against the Eagles last year as he managed only 2 catches for 28 yards (4.8 FP) in their Week 12 meeting.
Antonio Gates (SD @ Oak) – Gates is averaging only 7.0 FPG against the Raiders over the last two seasons. He failed to reach 35 yards in any of the three games in that span and has only scored once in his last five games in this matchup.